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KMID : 1123920090230020381
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Korean Journal of Oriental Physiology and Pathology
2009 Volume.23 No. 2 p.381 ~ p.388
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Inhibitory Effect of Galgeunhaegi-Tang on Compound48/80 Stimulated Allergic Reaction
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Kim Hyung-Kap
Shin Sang-Woo
Park Jong-Hyun
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Abstract
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The present study was conducted to investigate the anti-allergic activity of Galgeunhaegi-Tang(GHT). We investigated the anti-allergic effects of GHT in RBL-2H3 basophilic leukemia cells by compound48/80, a mast cell degranulator and compound 48/80 induced anaphylactic shock in mice. GHT significantly inhibited -hexosaminidase and histamine release from compound 48/80 stimulated RBL-2H3 cells. In addition, GHT effectively inhibited anaphylactic shock in mice by 40% at a dose 100 mg/mouse versus PBS treated control after the l.p injection(8 mg/kg) of compound 48/80. The in vitro anti-inflammatory activities of GHT in LPS-stimulated RAW 264.7 cells were investigated. GHT inhibited NO production in LPS-stimulated RAW 264.7 cells and effectively dowregulated the expression of iNOS mRNA and iNOS protein expression in LPS-stimulated RAW 264.7 cells. These result provide evidences that GHT may be beneficial in the treatment of allergic inflammtory disease.
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KEYWORD
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Galgeunhaegi-Tang, compound 48/80, -hexosaminidase, histamine release, nitric oxide
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